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Catalytic enantioselective synthesis of fluoromethylated stereocenters by asymmetric hydrogenation.

ABSTRACT: Fluoromethyl groups possess specific steric and electronic properties and serve as a bioisostere of alcohol, thiol, nitro, and other functional groups, which are important in an assortment of molecular recognition processes. Herein we report a catalytic method for the asymmetric synthesis of a variety of enantioenriched products bearing fluoromethylated stereocenters with excellent yields and enantioselectivities. Various N,P-ligands were designed and applied in the hydrogenation of fluoromethylated olefins and vinyl fluorides.

SUBMITTER: Yang J

PROVIDER: S-EPMC9337738 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Catalytic enantioselective synthesis of fluoromethylated stereocenters by asymmetric hydrogenation.

Yang Jianping J Ponra Sudipta S Li Xingzhen X Peters Bram B C BBC Massaro Luca L Zhou Taigang T Andersson Pher G PG

Chemical science 20220629 29

Fluoromethyl groups possess specific steric and electronic properties and serve as a bioisostere of alcohol, thiol, nitro, and other functional groups, which are important in an assortment of molecular recognition processes. Herein we report a catalytic method for the asymmetric synthesis of a variety of enantioenriched products bearing fluoromethylated stereocenters with excellent yields and enantioselectivities. Various N,P-ligands were designed and applied in the hydrogenation of fluoromethyl ...[more]

PMID: 35974749

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