Ontology highlight
ABSTRACT:
SUBMITTER: Sasai M
PROVIDER: S-EPMC3063333 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Sasai Miwa M Linehan Melissa M MM Iwasaki Akiko A
Science (New York, N.Y.) 20100901 5998
Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals leading to the activation of nuclear factor κB (NF-κB)-dependent proinflammatory cytokines and interferon regulatory factor 7 (IRF7)-dependent type I interferons (IFNs). Recognition of viral nucleic acids by TLR9 requires its cleavage in the endolysosomal compartment. Here, we show that TLR9 signals leading to the activation of type I IFN, but not proinflammatory cytokine genes, require TLR9 trafficking fro ...[more]