Ontology highlight
ABSTRACT:
SUBMITTER: Mantegazza AR
PROVIDER: S-EPMC3361531 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Mantegazza Adriana R AR Guttentag Susan H SH El-Benna Jamel J Sasai Miwa M Iwasaki Akiko A Shen Hao H Laufer Terri M TM Marks Michael S MS
Immunity 20120503 5
Effective major histocompatibility complex-II (MHC-II) antigen presentation from phagocytosed particles requires phagosome-intrinsic Toll-like receptor (TLR) signaling, but the molecular mechanisms underlying TLR delivery to phagosomes and how signaling regulates antigen presentation are incompletely understood. We show a requirement in dendritic cells (DCs) for adaptor protein-3 (AP-3) in efficient TLR recruitment to phagosomes and MHC-II presentation of antigens internalized by phagocytosis bu ...[more]