Ontology highlight
ABSTRACT:
SUBMITTER: Dose C
PROVIDER: S-EPMC3063708 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Dose Christian C Farkas Michelle E ME Chenoweth David M DM Dervan Peter B PB
Journal of the American Chemical Society 20080507 21
The characterization of a new class of pyrrole-imidazole hairpin polyamides with beta-amino-gamma-turn units for recognition of the DNA minor groove is reported. A library of eight hairpins containing ( R)- and ( S)-3,4-diaminobutyric acid (beta-amino-gamma-turn) has been synthesized, and the impact of the molecules on DNA-duplex stabilization was studied for comparison with the parent gamma-aminobutyric acid (gamma-turn) and standard ( R)-2,4-diaminobutyric acid (alpha-amino-gamma-turn)-linked ...[more]