Ontology highlight
ABSTRACT:
SUBMITTER: Farkas ME
PROVIDER: S-EPMC2140246 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Farkas Michelle E ME Tsai Sherry M SM Dervan Peter B PB
Bioorganic & medicinal chemistry 20070822 22
A hairpin polyamide-chlorambucil conjugate linked by alpha-diaminobutyric acid (alpha-DABA) has been shown to have interesting biological properties in cellular and small animal models. Remarkably, this new class of hairpin polyamides has not been previously characterized with regard to energetics and sequence specificity. Herein we present a series of pyrrole-imidazole hairpin polyamides linked by alpha-DABA and compare them to polyamides containing the standard gamma-DABA turn unit. The alpha- ...[more]