Ontology highlight
ABSTRACT:
SUBMITTER: Bomberger JM
PROVIDER: S-EPMC3063759 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Bomberger Jennifer M JM Ye Siying S Maceachran Daniel P DP Koeppen Katja K Barnaby Roxanna L RL O'Toole George A GA Stanton Bruce A BA
PLoS pathogens 20110324 3
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen chronically infecting the lungs of patients with chronic obstructive pulmonary disease (COPD), pneumonia, cystic fibrosis (CF), and bronchiectasis. Cif (PA2934), a bacterial toxin secreted in outer membrane vesicles (OMV) by P. aeruginosa, reduces CFTR-mediated chloride secretion by human airway epithelial cells, a key driving force for mucociliary clearance. The aim of this study was to investigate the mechanism whereby Cif red ...[more]