Ontology highlight
ABSTRACT:
SUBMITTER: Wong K
PROVIDER: S-EPMC6528793 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Wong Kathy K Perpich John D JD Kozlov Guennadi G Cygler Miroslaw M Abu Kwaik Yousef Y Gehring Kalle K
Structure (London, England : 1993) 20170119 2
Ankyrin B (AnkB/LegAU13) is a translocated F box effector essential for the intracellular replication of the pathogen Legionella pneumophila. AnkB co-opts a host ubiquitin ligase to decorate the pathogen-containing vacuole with K<sup>48</sup>-linked polyubiquitinated proteins and degrade host proteins as a source of energy. Here, we report that AnkB commandeers the host ubiquitin-proteasome system through mimicry of two eukaryotic protein domains. Using X-ray crystallography, we determined the 3 ...[more]