Ontology highlight
ABSTRACT:
SUBMITTER: Hur EM
PROVIDER: S-EPMC3064397 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Hur Eun-Mi EM Yang In Hong IH Kim Deok-Ho DH Byun Justin J Saijilafu Xu Wen-Lin WL Nicovich Philip R PR Cheong Raymond R Levchenko Andre A Thakor Nitish N Zhou Feng-Quan FQ
Proceedings of the National Academy of Sciences of the United States of America 20110307 12
Neurons in the central nervous system (CNS) fail to regenerate axons after injuries due to the diminished intrinsic axon growth capacity of mature neurons and the hostile extrinsic environment composed of a milieu of inhibitory factors. Recent studies revealed that targeting a particular group of extracellular inhibitory factors is insufficient to trigger long-distance axon regeneration. Instead of antagonizing the growing list of impediments, tackling a common target that mediates axon growth i ...[more]