Guiding neuronal growth cones using Ca2+ signals.
Ontology highlight
ABSTRACT:
SUBMITTER: Henley J
PROVIDER: S-EPMC3115711 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Publications
Guiding neuronal growth cones using Ca2+ signals.
Trends in cell biology 20040601 6
Pathfinding by growing axons in the developing or regenerating nervous system is guided by gradients of molecular guidance cues. The neuronal growth cone, located at the ends of axons, uses surface receptors to sense these cues and to transduce guidance information to cellular machinery that mediates growth and turning responses. Cytoplasmic Ca2+ signals have key roles in regulating this motility. Global growth cone Ca2+ signals can regulate cytoskeletal elements and membrane dynamics to control ...[more]
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