Ontology highlight
ABSTRACT:
SUBMITTER: Yu W
PROVIDER: S-EPMC3064775 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Yu Weishi W Qiu Zhongwei Z Gao Na N Wang Liren L Cui Hengxiang H Qian Yu Y Jiang Li L Luo Jian J Yi Zhengfang Z Lu Hua H Li Dali D Liu Mingyao M
Nucleic acids research 20101121 6
Cell growth and proliferation are tightly controlled via the regulation of the p53-MDM2 feedback loop in response to various cellular stresses. In this study, we identified a nucleolar protein called PAK1IP1 as another regulator of this loop. PAK1IP1 was induced when cells were treated with chemicals that disturb ribosome biogenesis. Overexpression of PAK1IP1 inhibited cell proliferation by inducing p53-dependent G1 cell-cycle arrest. PAK1IP1 bound to MDM2 and inhibited its ability to ubiquitina ...[more]