Ontology highlight
ABSTRACT:
SUBMITTER: Sasaki M
PROVIDER: S-EPMC4578312 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Sasaki Masato M Kawahara Kohichi K Nishio Miki M Mimori Koshi K Kogo Ryunosuke R Hamada Koichi K Itoh Bunsho B Wang Jia J Komatsu Yukako Y Yang Yong Ryoul YR Hikasa Hiroki H Horie Yasuo Y Yamashita Takayuki T Kamijo Takehiko T Zhang Yanping Y Zhu Yan Y Prives Carol C Nakano Toru T Mak Tak Wah TW Sasaki Takehiko T Maehama Tomohiko T Mori Masaki M Suzuki Akira A
Nature medicine 20110731 8
PICT1 (also known as GLTSCR2) is considered a tumor suppressor because it stabilizes phosphatase and tensin homolog (PTEN), but individuals with oligodendrogliomas lacking chromosome 19q13, where PICT1 is located, have better prognoses than other oligodendroglioma patients. To clarify the function of PICT1, we generated Pict1-deficient mice and embryonic stem (ES) cells. Pict1 is a nucleolar protein essential for embryogenesis and ES cell survival. Even without DNA damage, Pict1 loss led to p53- ...[more]