Ontology highlight
ABSTRACT:
SUBMITTER: Buckley PT
PROVIDER: S-EPMC3065018 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Buckley Peter T PT Lee Miler T MT Sul Jai-Yoon JY Miyashiro Kevin Y KY Bell Thomas J TJ Fisher Stephen A SA Kim Junhyong J Eberwine James J
Neuron 20110301 5
RNA precursors give rise to mRNA after splicing of intronic sequences traditionally thought to occur in the nucleus. Here, we show that intron sequences are retained in a number of dendritically-targeted mRNAs, by using microarray and Illumina sequencing of isolated dendritic mRNA as well as in situ hybridization. Many of the retained introns contain ID elements, a class of SINE retrotransposon. A portion of these SINEs confers dendritic targeting to exogenous and endogenous transcripts showing ...[more]