Ontology highlight
ABSTRACT:
SUBMITTER: Mak KS
PROVIDER: S-EPMC4056533 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mak Ka Sin KS Burdach Jon J Norton Laura J LJ Pearson Richard C M RC Crossley Merlin M Funnell Alister P W AP
Genome biology 20140430 4
<h4>Background</h4>Retroviral elements are pervasively transcribed and dynamically regulated during development. While multiple histone- and DNA-modifying enzymes have broadly been associated with their global silencing, little is known about how the many diverse retroviral families are each selectively recognized.<h4>Results</h4>Here we show that the zinc finger protein Krüppel-like Factor 3 (KLF3) specifically silences transcription from the ORR1A0 long terminal repeat in murine fetal and adul ...[more]