Ontology highlight
ABSTRACT:
SUBMITTER: Goldman SD
PROVIDER: S-EPMC3065188 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Goldman Stephen D B SD Funk Ryan S RS Rajewski Roger A RA Krise Jeffrey P JP
Bioanalysis 20091101 8
The human body is continuously exposed to small organic molecules containing one or more basic nitrogen atoms. Many of these are endogenous (i.e., neurotransmitters, polyamines and biogenic amines), while others are exogenously supplied in the form of drugs, foods and pollutants. It is well-known that many amines have a strong propensity to specifically and substantially accumulate in highly acidic intracellular compartments, such as lysosomes, through a mechanism referred to as ion trapping. It ...[more]