Ontology highlight
ABSTRACT:
SUBMITTER: Strbo N
PROVIDER: S-EPMC3065331 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Strbo Natasa N Vaccari Monica M Pahwa Savita S Kolber Michael A MA Fisher Eva E Gonzalez Louis L Doster Melvin N MN Hryniewicz Anna A Felber Barbara K BK Pavlakis George N GN Franchini Genoveffa G Podack Eckhard R ER
Vaccine 20110128 14
The ER-resident chaperone gp96, when released by cell lysis, induces an immunogenic chemokine signature and causes innate immune activation of DC and NK cells. Here we show that intraperitoneal immunization with a genetically engineered, secreted form of gp96, gp96-Ig chaperoning SIV antigens, induces high levels of antigen specific CD8 CTL in the rectal and vaginal mucosa of Rhesus macaques. The frequency of SIV Gag- and SIV Tat-tetramer positive CD8 CTL in the intestinal mucosa reached 30-50% ...[more]