Ontology highlight
ABSTRACT:
SUBMITTER: Hajikhezri Z
PROVIDER: S-EPMC7999198 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Hajikhezri Zamaneh Z Roohvand Farzin F Maleki Monireh M Shahmahmoodi Shohreh S Amirzargar Ali Akbar AA Keshavarz Abolfazl A Seyed Negar N Farahmand Mohammad M Samimi-Rad Katayoun K
Vaccines 20210303 3
Feeble cellular responses induced by T cell-based vaccines are a major challenge for the development of an effective vaccine against Hepatitis C virus (HCV) infection. To address this challenge, the potential of N-terminal fragment of gp96 heat shock protein (rNT (gp96) as an adjuvant was evaluated and compared to that of the CpG (as a recognized Th1-type adjuvant) in the formulation of HCV core/NS3 antigens in three immunization strategies of protein/protein, DNA/DNA, and DNA/protein. Immunized ...[more]