Ontology highlight
ABSTRACT:
SUBMITTER: Finley LW
PROVIDER: S-EPMC3065720 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Finley Lydia W S LW Carracedo Arkaitz A Lee Jaewon J Souza Amanda A Egia Ainara A Zhang Jiangwen J Teruya-Feldstein Julie J Moreira Paula I PI Cardoso Sandra M SM Clish Clary B CB Pandolfi Pier Paolo PP Haigis Marcia C MC
Cancer cell 20110301 3
Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates required for biomass generation. Here, we show that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect. Mechanistically, SIRT3 mediates metabolic reprogramming by destabilizing hypoxia-inducible factor-1α (HIF1α), a transcription factor that controls ...[more]