Dataset Information

Polygenic dissection of the bipolar phenotype.

ABSTRACT:

Background

Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder.

Aims

To test hypotheses about the relationship between schizophrenia and psychotic types of bipolar disorder.

Method

Using a polygenic score analysis to test whether schizophrenia polygenic risk alleles, en masse, significantly discriminate between individuals with bipolar disorder with and without psychotic features. The primary sample included 1829 participants with bipolar disorder and the replication sample comprised 506 people with bipolar disorder.