Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans.
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ABSTRACT:
SUBMITTER: Kohli U
PROVIDER: S-EPMC3065933 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
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Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans.
Kohli Utkarsh U Hahn Maureen K MK English Brett A BA Sofowora Gbenga G GG Muszkat Mordechai M Li Chun C Blakely Randy D RD Stein C Michael CM Kurnik Daniel D
Pharmacogenetics and genomics 20110401 4
<h4>Background</h4>The presynaptic norepinephrine transporter (NET) mediates synaptic clearance and recycling of norepinephrine. NET-deficient transgenic mice have elevated blood pressure (BP), heart rate, and catecholamine concentrations. However, the in-vivo effects of common NET variants on cardiovascular regulation at rest and during exercise are unknown.<h4>Methods</h4>We studied cardiovascular responses and plasma catecholamine concentrations at rest and during bicycle exercise at increasi ...[more]
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2008-06-23 | GSE11788 | GEO
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2008-06-23 | E-GEOD-11788 | biostudies-arrayexpress
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