Ontology highlight
ABSTRACT:
SUBMITTER: Fujino T
PROVIDER: S-EPMC3065975 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Fujino Tadahiro T Lee Wei-Chung Allen WC Nedivi Elly E
Molecular and cellular neurosciences 20031101 3
Transcriptional activation is a key link between neuronal activity and long-term synaptic plasticity. Little is known about genes responding to this activation whose products directly effect functional and structural changes at the synapse. cpg15 is an activity-regulated gene encoding a membrane-bound ligand that regulates dendritic and axonal arbor growth and synaptic maturation. We report that cpg15 is an immediate-early gene induced by Ca(2+) influx through NMDA receptors and L-type voltage-s ...[more]