Ontology highlight
ABSTRACT:
SUBMITTER: Mills F
PROVIDER: S-EPMC5373847 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Mills Fergil F Globa Andrea K AK Liu Shuai S Cowan Catherine M CM Mobasser Mahsan M Phillips Anthony G AG Borgland Stephanie L SL Bamji Shernaz X SX
Nature neuroscience 20170213 4
Drugs of abuse alter synaptic connections in the reward circuitry of the brain, which leads to long-lasting behavioral changes that underlie addiction. Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes driven by cocaine. We demonstrate that cadherin is essential for long-term potentiation in the ventral tegmental area and is recruited to the synaptic membranes of excitatory synapses onto dopaminergic neurons following cocai ...[more]