Positive selection of tyrosine loss in metazoan evolution.
Ontology highlight
ABSTRACT:
SUBMITTER: Tan CS
PROVIDER: S-EPMC3066034 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Publications
Positive selection of tyrosine loss in metazoan evolution.
Tan Chris Soon Heng CS Pasculescu Adrian A Lim Wendell A WA Pawson Tony T Bader Gary D GD Linding Rune R
Science (New York, N.Y.) 20090709 5948
John Nash showed that within a complex system, individuals are best off if they make the best decision that they can, taking into account the decisions of the other individuals. Here, we investigate whether similar principles influence the evolution of signaling networks in multicellular animals. Specifically, by analyzing a set of metazoan species we observed a striking negative correlation of genomically encoded tyrosine content with biological complexity (as measured by the number of cell typ ...[more]
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