The evolution of metazoan shelterin.
Ontology highlight
ABSTRACT:
SUBMITTER: Myler LR
PROVIDER: S-EPMC8653790 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
The evolution of metazoan shelterin.
Myler Logan R LR Kinzig Charles G CG Sasi Nanda K NK Zakusilo George G Cai Sarah W SW de Lange Titia T
Genes & development 20211111 23-24
The mammalian telomeric shelterin complex-comprised of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1-blocks the DNA damage response at chromosome ends and interacts with telomerase and the CST complex to regulate telomere length. The evolutionary origins of shelterin are unclear, partly because unicellular organisms have distinct telomeric proteins. Here, we describe the evolution of metazoan shelterin, showing that TRF1 emerged in vertebrates upon duplication of a TRF2-like ancestor. TRF1 and TRF2 div ...[more]
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