Dataset Information
Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander.
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ABSTRACT: Background
We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.Methods
From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.Results
HRVs were detected in 315 (16%) of 1919 hospitalized patients and 27 (9.6%) of 280 controls. Children had the highest frequency of HRV detections (hospitalized: <1 year: 29%, 1-4 year: 29%, ? 65 years: 9%; controls: <1 year: 24%, 1-4 year: 14%, ? 65 years: 2.8%). Enrollment adjusted hospitalized HRV detection rates were highest among persons aged <1 year (1038/100,000 persons/year), 1-4 years (457), and ? 65 years (71). All three HRV species were identified, HRV-A was the most common species in most age groups including children aged <1 year (61%) and all adult age groups. HRV-C was the most common species in the 1-4 year (51%) and 5-19 year age groups (54%). Compared to controls, hospitalized adults (? 19 years) and children were more likely to have HRV detections (odds ratio [OR]: 4.8, 95% confidence interval [CI]: 1.5, 15.8; OR: 2.0, CI: 1.2, 3.3, respectively) and hospitalized children were more likely to have HRV-A (OR 1.7, CI: 0.8, 3.5) or HVR-C (OR 2.7, CI: 1.2, 5.9) detection.Conclusions
HRV rates were high among hospitalized children and the elderly but asymptomatic children also had substantial HRV detection. HRV (all species), and HRV-A and HRV-C detections were epidemiologically-associated with hospitalized illness. Treatment or prevention modalities effective against HRV could reduce hospitalizations due to HRV in Thailand.
SUBMITTER: Fry AM
PROVIDER: S-EPMC3066183 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander.
PloS one 20110329 3
<h4>Background</h4>We describe human rhinovirus (HRV) detections in SaKaeo province, Thailand.<h4>Methods</h4>From September 1, 2003-August 31, 2005, we tested hospitalized patients with acute lower respiratory illness and outpatient controls without fever or respiratory symptoms for HRVs with polymerase chain reaction and molecularly-typed select HRVs. We compared HRV detection among hospitalized patients and controls and estimated enrollment adjusted incidence.<h4>Results</h4>HRVs were detecte ...[more]
