Ontology highlight
ABSTRACT:
SUBMITTER: Reddy MM
PROVIDER: S-EPMC3066439 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Reddy M Muralidhar MM Wilson Rosemary R Wilson Johnnie J Connell Steven S Gocke Anne A Hynan Linda L German Dwight D Kodadek Thomas T
Cell 20110101 1
The adaptive immune system is thought to be a rich source of protein biomarkers, but diagnostically useful antibodies remain unknown for a large number of diseases. This is, in part, because the antigens that trigger an immune response in many diseases remain unknown. We present here a general and unbiased approach to the identification of diagnostically useful antibodies that avoids the requirement for antigen identification. This method involves the comparative screening of combinatorial libra ...[more]