Ontology highlight
ABSTRACT:
SUBMITTER: Turgeon Z
PROVIDER: S-EPMC3067067 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20101206 3
The mono-ADP-ribosyltransferase toxins are bacterial virulence factors that contribute to many disease states in plants, animals, and humans. These toxins function as enzymes that target various host proteins and covalently attach an ADP-ribose moiety that alters target protein function. We tested compounds from a virtual screen of commercially available compounds combined with a directed poly(ADP-ribose) polymerase (PARP) inhibitor library and found several compounds that bind tightly and inhib ...[more]