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FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy.

ABSTRACT: This is the first case report of Candida glabrata-disseminated candidiasis describing the acquisition of echinocandin resistance following anidulafungin treatment. The initial isolates recovered were susceptible to echinocandins. However, during 27 days of anidulafungin treatment, two resistant strains were isolated (from the blood and peritoneal fluid). The resistant peritoneal fluid isolate exhibited a Ser663Pro mutation in position 1987 of FKS2 HS1 (hot spot 1), whereas the resistant blood isolate displayed a phenylalanine deletion (Phe659).

SUBMITTER: Costa-de-Oliveira S

PROVIDER: S-EPMC3067100 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy.

Costa-de-Oliveira Sofia S Marcos Miranda Isabel I Silva Raquel M RM Silva Raquel M RM Pinto E Silva Ana A Rocha Rita R Amorim António A Gonçalves Rodrigues Acácio A Pina-Vaz Cidália C

Antimicrobial agents and chemotherapy 20101213 3

This is the first case report of Candida glabrata-disseminated candidiasis describing the acquisition of echinocandin resistance following anidulafungin treatment. The initial isolates recovered were susceptible to echinocandins. However, during 27 days of anidulafungin treatment, two resistant strains were isolated (from the blood and peritoneal fluid). The resistant peritoneal fluid isolate exhibited a Ser663Pro mutation in position 1987 of FKS2 HS1 (hot spot 1), whereas the resistant blood is ...[more]

PMID: 21149621

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