Ontology highlight
ABSTRACT:
SUBMITTER: Coste AT
PROVIDER: S-EPMC7518979 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Coste A T AT Kritikos A A Li J J Khanna N N Goldenberger D D Garzoni C C Zehnder C C Boggian K K Neofytos D D Riat A A Bachmann D D Sanglard D D Lamoth F F
Infection 20200713 5
Echinocandins represent the first-line therapy of candidemia. Echinocandin resistance among Candida spp. is mainly due to acquired FKS mutations. In this study, we report the emergence of FKS-mutant Candida albicans/glabrata in Switzerland and provide the microbiological and clinical characteristics of 9 candidemic episodes. All patients were previously exposed to echinocandins (median 26 days; range 15-77). Five patients received initial echinocandin therapy with persistent candidemia in 4 of t ...[more]