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Interspecies dissemination of the bla gene encoding PER-1 extended-spectrum ?-lactamase.

ABSTRACT: PER-1 extended-spectrum ?-lactamase-producing Gram-negative bacilli are resistant to oxyimino-cephalosporins. However, the bla(PER-1) gene has never been reported in Klebsiella pneumoniae. Here, we studied interspecies dissemination of the bla(PER-1) gene by horizontal transfer of Tn1213 among Acinetobacter baumannii, Pseudomonas aeruginosa, and K. pneumoniae. In a K. pneumoniae clinical isolate, the bla(PER-1) gene was located on a 150-kbp incompatibility group A/C plasmid.

SUBMITTER: Bae IK

PROVIDER: S-EPMC3067111 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Interspecies dissemination of the bla gene encoding PER-1 extended-spectrum β-lactamase.

Bae Il Kwon IK Jang Sook Jin SJ Kim Juwon J Jeong Seok Hoon SH Cho Byungkyu B Lee Kyungwon K

Antimicrobial agents and chemotherapy 20101213 3

PER-1 extended-spectrum β-lactamase-producing Gram-negative bacilli are resistant to oxyimino-cephalosporins. However, the bla(PER-1) gene has never been reported in Klebsiella pneumoniae. Here, we studied interspecies dissemination of the bla(PER-1) gene by horizontal transfer of Tn1213 among Acinetobacter baumannii, Pseudomonas aeruginosa, and K. pneumoniae. In a K. pneumoniae clinical isolate, the bla(PER-1) gene was located on a 150-kbp incompatibility group A/C plasmid. ...[more]

PMID: 21149630

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