Ontology highlight
ABSTRACT:
SUBMITTER: Lee NS
PROVIDER: S-EPMC3067365 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Lee Nam-Sihk NS Barber Laura L Kanchwala Ali A Childs Carter J H CJ Kataria Yash P YP Judson Marc A MA Mazer Mark A MA Arce Sergio S
Clinical and vaccine immunology : CVI 20101222 2
T lymphocytes from patients with sarcoidosis respond weakly when stimulated with mitogen or antigen. However, the mechanisms responsible for this anergy are not fully understood. Here, we investigated the protein levels of nuclear transcription factor NF-κB (p50, p65, and p105), IκBα (inhibitor of NF-κB), T-cell receptor (TCR) CD3ζ-chain, tyrosine kinase p56(LCK), and nuclear factor of activated T cells c2 (NF-ATc2) in peripheral blood CD4(+) T cells from patients with sarcoidosis. Baseline expr ...[more]