Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3.
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ABSTRACT:
SUBMITTER: Argimon S
PROVIDER: S-EPMC3067398 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Publications
Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3.
Argimón Silvia S Fanning Saranna S Blankenship Jill R JR Mitchell Aaron P AP
Eukaryotic cell 20101203 2
Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury. ...[more]
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