Ontology highlight
ABSTRACT:
SUBMITTER: Krantz M
PROVIDER: S-EPMC2710867 | biostudies-other | 2009
REPOSITORIES: biostudies-other
Krantz Marcus M Ahmadpour Doryaneh D Ottosson Lars-Göran LG Warringer Jonas J Waltermann Christian C Nordlander Bodil B Klipp Edda E Blomberg Anders A Hohmann Stefan S Kitano Hiroaki H
Molecular systems biology 20090616
Cellular signalling networks integrate environmental stimuli with the information on cellular status. These networks must be robust against stochastic fluctuations in stimuli as well as in the amounts of signalling components. Here, we challenge the yeast HOG signal-transduction pathway with systematic perturbations in components' expression levels under various external conditions in search for nodes of fragility. We observe a substantially higher frequency of fragile nodes in this signal-trans ...[more]