Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez H
PROVIDER: S-EPMC3069107 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Alvarez Hector H Opalinska Joanna J Zhou Li L Sohal Davendra D Fazzari Melissa J MJ Yu Yiting Y Montagna Christina C Montgomery Elizabeth A EA Canto Marcia M Dunbar Kerry B KB Wang Jean J Roa Juan Carlos JC Mo Yongkai Y Bhagat Tushar T Ramesh K H KH Cannizzaro Linda L Mollenhauer J J Thompson Reid F RF Suzuki Masako M Meltzer Stephen J SJ Melnick Ari A Greally John M JM Maitra Anirban A Verma Amit A
PLoS genetics 20110331 3
Although a combination of genomic and epigenetic alterations are implicated in the multistep transformation of normal squamous esophageal epithelium to Barrett esophagus, dysplasia, and adenocarcinoma, the combinatorial effect of these changes is unknown. By integrating genome-wide DNA methylation, copy number, and transcriptomic datasets obtained from endoscopic biopsies of neoplastic progression within the same individual, we are uniquely able to define the molecular events associated progress ...[more]