Bioactive compounds from the fern Lepisorus contortus.

ABSTRACT: Phytochemical investigation of the whole plant of Lepisorus contortus (Christ) Ching led to the isolation of five new phenylethanoid glycosides (1-5), each containing a caffeoyl group, a new flavonoid glycoside (10), and 14 known compounds (6-9 and 11-15, syringic acid, vanillic acid, phloretic acid, diplopterol, and ?-sitosterol). This is the first report of phenylethanoid glycosides from the family Polypodiaceae. Compounds 1-15 were evaluated for their cancer chemopreventive potential based on their ability to inhibit tumor necrosis factor alpha (TNF-?)-induced NF-?B activity, nitric oxide (NO) production, and aromatase, quinone reductase 2 (QR-2), and COX-1/-2 activities. Quercetin-3-O-?-d-glucoside (15) demonstrated inhibition against QR2 with an IC(50) value of 3.84 ?M, which confirmed kaempferol/quercetin glycosides as the active compounds to inhibit QR2. The compound also demonstrated NF-?B activity with an IC(50) value of 33.6 ?M. In addition, compounds 1, 2, 4, and 6 showed aromatase activity with IC(50) values of 30.7, 32.3, 26.8, and 35.3 ?M, respectively.

SUBMITTER: Yang JH 

PROVIDER: S-EPMC3069126 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature