Ontology highlight
ABSTRACT:
SUBMITTER: Lin SJ
PROVIDER: S-EPMC3069177 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Lin S Jack SJ Hu Yaoxiong Y Zhu Jie J Woodruff Teresa K TK Jardetzky Theodore S TS
Proceedings of the National Academy of Sciences of the United States of America 20110314 13
The zona pellucida (ZP) domain is a bipartite protein structural element comprised of ZP-N and ZP-C regions. Most notable for its ability to mediate protein polymerization, many ZP proteins polymerize and assemble into long fibrils that form specialized extracellular matrices. Other ZP proteins (namely, betaglycan and endoglin) do not polymerize but serve as important membrane coreceptors for ligands in the transforming growth factor-β (TGF-β) superfamily. Here, we present the 2.0-Å resolution c ...[more]