Ontology highlight
ABSTRACT:
SUBMITTER: Cohen JD
PROVIDER: S-EPMC7665627 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Cohen Jennifer D JD Bermudez Jessica G JG Good Matthew C MC Sundaram Meera V MV
PLoS genetics 20201103 11
Zona Pellucida domain (ZP) proteins are critical components of the body's external-most protective layers, apical extracellular matrices (aECMs). Although their loss or dysfunction is associated with many diseases, it remains unclear how ZP proteins assemble in aECMs. Current models suggest that ZP proteins polymerize via their ZPn subdomains, while ZPc subdomains modulate ZPn behavior. Using the model organism C. elegans, we investigated the aECM assembly of one ZP protein, LET-653, which shape ...[more]