Ontology highlight
ABSTRACT:
SUBMITTER: Houston EG
PROVIDER: S-EPMC3069187 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Houston Evan G EG Higdon Lauren E LE Fink Pamela J PJ
Proceedings of the National Academy of Sciences of the United States of America 20110314 13
Recent thymic emigrants (RTEs) are the youngest subset of peripheral T cells, and they differ functionally and phenotypically from the rest of the naïve T-cell pool. RTEs are present in the peripheral T-cell pool throughout life but are the most common subset of T cells in neonates and adults recovering from lymphoablation. Using a murine model to study the homeostasis of RTEs, we show that under lymphoreplete conditions, RTEs are at a competitive disadvantage to already established mature naïve ...[more]