Dynamics of Recent Thymic Emigrants in Young Adult Mice.

ABSTRACT: The peripheral naive T-cell pool is generally thought to consist of a subpopulation of recent thymic emigrants (RTEs) and a subpopulation of mature naive (MN) T cells with different dynamics. Thymus transplantation and adoptive transfer studies in mice have provided contradicting results, with some studies suggesting that RTEs are relatively short-lived cells, while another study suggested that RTEs have a survival advantage. We here estimate the death rates of RTE and MN T cells by performing both thymus transplantations and deuterium labeling experiments in mice of at least 12 weeks old, an age at which the size of the T-cell pool has stabilized. For CD4⁺ T cells, we found the total loss rate from the RTE compartment (by death and maturation) to be fourfold faster than that of

SUBMITTER: van Hoeven V 

PROVIDER: S-EPMC5545745 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature