Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3069673 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Li Hojun H Malani Nirav N Hamilton Shari R SR Schlachterman Alexander A Bussadori Giulio G Edmonson Shyrie E SE Shah Rachel R Arruda Valder R VR Mingozzi Federico F Wright J Fraser JF Bushman Frederic D FD High Katherine A KA
Blood 20101124 12
Gene transfer using adeno-associated virus (AAV) vectors has great potential for treating human disease. Recently, questions have arisen about the safety of AAV vectors, specifically, whether integration of vector DNA in transduced cell genomes promotes tumor formation. This study addresses these questions with high-dose liver-directed AAV-mediated gene transfer in the adult mouse as a model (80 AAV-injected mice and 52 controls). After 18 months of follow-up, AAV-injected mice did not show a si ...[more]