Ontology highlight
ABSTRACT:
SUBMITTER: Hai M
PROVIDER: S-EPMC6291306 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Hai M M Adler R L RL Bauer T R TR Tuschong L M LM Gu Y-C YC Wu X X Hickstein D D DD
Gene therapy 20080327 14
Integration site analysis was performed on six dogs with canine leukocyte adhesion deficiency (CLAD) that survived greater than 1 year after infusion of autologous CD34+ bone marrow cells transduced with a gammaretroviral vector expressing canine CD18. A total of 387 retroviral insertion sites (RIS) were identified in the peripheral blood leukocytes from the six dogs at 1 year postinfusion. A total of 129 RIS were identified in CD3+ T-lymphocytes and 102 RIS in neutrophils from two dogs at 3 yea ...[more]