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ABSTRACT:
SUBMITTER: Krissinel E
PROVIDER: S-EPMC3069753 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Acta crystallographica. Section D, Biological crystallography 20110318 Pt 4
This paper presents a discussion of existing methods for the analysis of macromolecular interactions and complexes in crystal packing. Typical situations and conditions where wrong answers may be obtained in the course of ordinary procedures are presented and discussed. The more general question of what the relationship is between natural (in-solvent) and crystallized assemblies is discussed and researched. A computational analysis suggests that weak interactions with K(d) ≥ 100 µM have a consid ...[more]