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Nucleating the assembly of macromolecular complexes.

ABSTRACT: Nature constructs intricate complexes containing numerous binding partners in order to direct a variety of cellular processes. Researchers have taken a cue from these events to develop synthetic molecules that can nucleate natural and unnatural interactions for a diverse set of applications. These molecules can be designed to drive protein dimerization or to modulate the interactions between proteins, lipids, DNA, or RNA and thereby alter cellular pathways. A variety of components within the cellular machinery can be recruited with or replaced by synthetic compounds. Directing the formation of multicomponent complexes with new synthetic molecules can allow unprecedented control over the cellular machinery.

SUBMITTER: Peterson-Kaufman KJ

PROVIDER: S-EPMC4176617 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Nucleating the assembly of macromolecular complexes.

Peterson-Kaufman Kimberly J KJ Carlson Clayton D CD Rodríguez-Martínez José A JA Ansari Aseem Z AZ

Chembiochem : a European journal of chemical biology 20100901 14

Nature constructs intricate complexes containing numerous binding partners in order to direct a variety of cellular processes. Researchers have taken a cue from these events to develop synthetic molecules that can nucleate natural and unnatural interactions for a diverse set of applications. These molecules can be designed to drive protein dimerization or to modulate the interactions between proteins, lipids, DNA, or RNA and thereby alter cellular pathways. A variety of components within the cel ...[more]

PMID: 20812316

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