Ontology highlight
ABSTRACT:
SUBMITTER: Lv H
PROVIDER: S-EPMC3069776 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Lv Huijuan H Havari Evis E Pinto Sheena S Gottumukkala Raju V S R K RV Cornivelli Lizbeth L Raddassi Khadir K Matsui Takashi T Rosenzweig Anthony A Bronson Roderick T RT Smith Ross R Fletcher Anne L AL Turley Shannon J SJ Wucherpfennig Kai K Kyewski Bruno B Lipes Myra A MA
The Journal of clinical investigation 20110323 4
Autoimmunity has long been linked to myocarditis and its sequela, dilated cardiomyopathy, the leading causes of heart failure in young patients. However, the underlying mechanisms are poorly defined, with most clinical investigations focused on humoral autoimmunity as the target for intervention. Here, we show that the α-isoform of myosin heavy chain (α-MyHC, which is encoded by the gene Myh6) is the pathogenic autoantigen for CD4+ T cells in a spontaneous mouse model of myocarditis. Further, we ...[more]