Role of impaired central tolerance to ?-myosin in inflammatory heart disease.
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ABSTRACT:
SUBMITTER: Lv H
PROVIDER: S-EPMC3472104 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Role of impaired central tolerance to α-myosin in inflammatory heart disease.
Trends in cardiovascular medicine 20120701 5
For more than a half century, autoimmunity has been linked to a diverse array of heart diseases, including rheumatic carditis, myocarditis, Chagas' cardiomyopathy, post-myocardial infarction (Dressler's) syndrome, and idiopathic dilated cardiomyopathy. Why the heart is targeted by autoimmunity in these seemingly unrelated conditions has remained enigmatic. Here, we discuss our recent studies indicating that this susceptibility is mediated by impaired negative selection of autoreactive α-myosin h ...[more]
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