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Stachylines A-D from the sponge-derived fungus Stachylidium sp.

ABSTRACT: The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Four new, putatively tyrosine-derived and O-prenylated natural products, stachylines A-D (1-4), were obtained from the fungal extract. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compound 2 was established by Mosher's method. Stachyline A (1) possesses a rare terminal oxime group and occurs as an interchangeable mixture of E/Z-isomers.

SUBMITTER: Almeida C

PROVIDER: S-EPMC3070797 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Stachylines A-D from the sponge-derived fungus Stachylidium sp.

Almeida Celso C Part Natalja N Bouhired Sarah S Kehraus Stefan S König Gabriele M GM

Journal of natural products 20101216 1

The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Four new, putatively tyrosine-derived and O-prenylated natural products, stachylines A-D (1-4), were obtained from the fungal extract. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compound 2 was established by Mosher's method. Stachyline A (1) possesses a rare terminal oxime group and occurs as an interchangeable mixture of ...[more]

PMID: 21162532

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