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5-Hydroxycyclopenicillone, a New ?-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34.

ABSTRACT: Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehensive spectroscopic analyses. The absolute configuration of 1 was determined by comparison of electronic circular dichroism (ECD) spectra with literature values used for the reported analogue, cyclopenicillone (5), which was not isolated in this research. Compound 1 was shown to scavenge 2,2-diphenyl-1-picrylhydrazyl free radicals, and decrease ?-amyloid (A?) fibrillization in vitro. Moreover, 1 significantly reduced H?O?-induced neurotoxicity in SH-SY5Y cells. These findings suggested that compound 1, a newly discovered cyclopentenone, has moderate anti-oxidative, anti-A? fibrillization properties and neuroprotective effects, and might be a good free radical scavenger.

SUBMITTER: Fang F 

PROVIDER: S-EPMC5577614 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34.

Fang Fang F   Zhao Jiaying J   Ding Lijian L   Huang Chunhui C   Naman C Benjamin CB   He Shan S   Wu Bin B   Zhu Peng P   Luo Qijun Q   Gerwick William H WH   Yan Xiaojun X   Wang Qinwen Q   Zhang Zaijun Z   Cui Wei W  

Marine drugs 20170819 8

<b>Abstract</b><b>:</b> A new cyclopentenone, 5-hydroxycyclopeni cillone (<b>1</b>), was isolated together with three known compounds, <i>ar</i>-turmerone (<b>2</b>), citreoisocoumarin (<b>3</b>), and 6-O-methyl-citreoisocoumarin (<b>4</b>), from a culture of the sponge-derived fungus <i>Trichoderma</i> sp<i>.</i> HPQJ-34. The structures of <b>1</b>-<b>4</b> were characterized using comprehensive spectroscopic analyses. The absolute configuration of <b>1</b> was determined by comparison of elect  ...[more]

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