Ontology highlight
ABSTRACT:
SUBMITTER: Imwong M
PROVIDER: S-EPMC3071051 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20101209 2
Resistance of vivax malaria to treatment with antifolates, such as pyrimethamine (Pyr), is spreading as mutations in the dihydrofolatereductase (dhfr) genes are selected and disseminated. We tested the antitumor drug methotrexate (MTX), a potent competitive inhibitor of dhfr, against 11 Plasmodium vivax isolates ex vivo, 10 of which had multiple dhfr mutations associated with Pyr resistance. Despite high-grade resistance to Pyr (median 50% inhibitory concentration [IC₅₀], 13,345 nM), these paras ...[more]