Ontology highlight
ABSTRACT:
SUBMITTER: Fellay J
PROVIDER: S-EPMC3071133 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Fellay Jacques J Frahm Nicole N Shianna Kevin V KV Cirulli Elizabeth T ET Casimiro Danilo R DR Robertson Michael N MN Haynes Barton F BF Geraghty Daniel E DE McElrath M Juliana MJ Goldstein David B DB
The Journal of infectious diseases 20110128 6
Understanding how human genetic variation impacts individual response to immunogens is fundamental for rational vaccine development. To explore host mechanisms involved in cellular immune responses to the MRKAd5 human immunodeficiency virus type 1 (HIV-1) gag/pol/nef vaccine tested in the Step trial, we performed a genome-wide association study of determinants of HIV-specific T cell responses, measured by interferon γ enzyme-linked immunospot assays. No human genetic variant reached genome-wide ...[more]