Ontology highlight
ABSTRACT:
SUBMITTER: Kumar K
PROVIDER: S-EPMC3071426 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Kumar Kunal K Awasthi Divya D Lee Seung-Yub SY Zanardi Ilaria I Ruzsicska Bela B Knudson Susan S Tonge Peter J PJ Slayden Richard A RA Ojima Iwao I
Journal of medicinal chemistry 20101202 1
Libraries of novel trisubstituted benzimidazoles were created through rational drug design. A good number of these benzimidazoles exhibited promising MIC values in the range of 0.5-6 μg/mL (2-15 μM) for their antibacterial activity against Mtb H37Rv strain. Moreover, five of the lead compounds also exhibited excellent activity against clinical Mtb strains with different drug-resistance profiles. All lead compounds did not show appreciable cytotoxicity (IC(50) > 200 μM) against Vero cells, which ...[more]