Ontology highlight
ABSTRACT:
SUBMITTER: Staton AA
PROVIDER: S-EPMC3071589 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Nature genetics 20110123 3
microRNAs (miRNAs) function as genetic rheostats to control gene output. Based on their role as modulators, it has been postulated that miRNAs canalize development and provide genetic robustness. Here, we uncover a previously unidentified regulatory layer of chemokine signaling by miRNAs that confers genetic robustness on primordial germ cell (PGC) migration. In zebrafish, PGCs are guided to the gonad by the ligand Sdf1a, which is regulated by the sequestration receptor Cxcr7b. We find that miR- ...[more]